SHH激活型髓母细胞瘤中miRNA表达失调的分子机制
Molecular mechanisms of miRNA expression dysregulation in SHH-activated subtype medulloblastoma
Note： A. Correlation analysis of miRNA and mRNA expression profiles across P60 cerebellum and DMSO-treated or GDC-0449-treated P7 cerebellum. B. Identification of Hh pathway-dependent differentially expressed miRNAs in the P7 cerebellum. C. Identification of Hh pathway-dependent differentially expressed mRNAs in the P7 cerebellum. Foxj1—forkhead box J1; Gli2—GLI family zinc finger 2; Ptch2—patched 2; Atoh1—atonal homolog 1; E2f2—E2F transcription factor 2; Usp44—ubiquitin specific peptidase 44; Cdk6—cyclin-dependent kinase 6. D. Venn diagrams of the overlap of Hh pathway-dependent miRNAs and mRNAs among mouse SHH-MB models and the P7 cerebellum. E. Regulatory network of miR-204-5p and its predicted target genes. Tox3—TOX high mobility group box family member 3; Tnfaip8—TNF alpha-induced protein 8; Aurkb—aurora kinase B; Has2—hyaluronan synthase 2; Arhgef39—Rho guanine nucleotide exchange factor 39; Ticam2—TIR domain-containing adaptor molecule 2; Rtkn2—rhotekin 2; Rad51—RAD51 recombinase; Angptl2—angiopoietin-like 2; Cxcr4—C-X-C motif chemokine receptor 4; Esco2—establishment of sister chromatid cohesion N-acetyltransferase 2; Ncapd2—non-SMC condensin I complex subunit D2; Arhgap11a—Rho GTPase-activating protein 11A; Smc2—structural maintenance of chromosomes 2; Ccnd2—cyclin D2; Slc43a1—solute carrier family 43 member 1; Mad2l1—mitotic arrest deficient 2-like 1; Crybg3—crystallin beta-gamma domain containing 3; Dcc—DCC netrin 1 receptor; Cdc25b—cell division cycle 25B. F. KEGG pathway enrichment of the target genes.
