SHH激活型髓母细胞瘤中miRNA表达失调的分子机制

朱颖, 隋怡, 唐玉杰

Molecular mechanisms of miRNA expression dysregulation in SHH-activated subtype medulloblastoma

Zhu Ying, Sui Yi, Tang Yujie

图6 SHH-MB患者肿瘤组织miRNAs/mRNAs表达特征及人鼠保守性分析 Note： A. mRNA expression of Hh pathway genes (GLI1, GLI2) and miRNA biogenesis genes in SHH-MB patient tumors and normal cerebellum tissues (U133p2 dataset; ①P<0.001, ②P=0.010). B. Correlation analysis of miRNA expression profiles in SHH-MB patient tumors and normal cerebellum tissues (GSE42657 dataset). C. Volcano plot of differentially expressed miRNAs between SHH-MB and normal cerebellum tissues (GSE42657 dataset). FDR—false discovery rate; FC—fold change. D. Conserved differentially expressed miRNAs between SHH-MB patient tumors and mouse SHH-MB models. E. Conserved differentially expressed mRNAs between SHH-MB patient tumors and mouse SHH-MB models. F/G. KEGG pathway enrichment of predicted target genes of conserved up-regulated miRNAs (F) and down-regulated miRNAs (G). AGE—advanced glycation end products; RAGE—receptor for advanced glycation end products; ECM—extracellular matrix.

Fig 6 Expression characteristics of miRNAs/mRNAs in tumor tissues from SHH-MB patients and human-mouse conservation analysis