金丝桃素通过抑制NF-κB信号通路减轻糖尿病肾病足细胞损伤

韩珍, 王浩, 苏秀秀, 方际

Hypericin alleviates podocyte injury in diabetic nephropathy by inhibiting the NF-κB signaling pathway

Han Zhen, Wang Hao, Su Xiuxiu, Fang Ji

图5 HE、PAS染色、免疫组化、透射电镜评估肾组织病理学变化 Note： HYP ameliorated podocyte injury in db/db mice. A. HE staining showed histopathological changes in glomeruli across groups (×400). B. PAS staining revealed glomerular basement membrane thickness and mesangial matrix expansion in each group (×400). C. WT-1 expression in mouse glomeruli from different groups (×400). D. Transmission electron microscopy showed podocyte foot process effacement (×20 000). Scale bars=20 μm (A, B, C); 500 nm (D).

Fig 5 Renal histopathological changes were evaluated by HE staining, PAS staining, immunohistochemistry, and transmission electron microscopy