金丝桃素通过抑制NF-κB信号通路减轻糖尿病肾病足细胞损伤

韩珍, 王浩, 苏秀秀, 方际

Hypericin alleviates podocyte injury in diabetic nephropathy by inhibiting the NF-κB signaling pathway

Han Zhen, Wang Hao, Su Xiuxiu, Fang Ji

图8 蛋白质印迹法检测HYP对WT-1蛋白及NF-κB信号通路蛋白表达的影响 Note： The effect of HYP on the expression of WT-1 protein and NF-κB signaling pathway-related proteins. A. Western blotting analysis of WT-1, p-NF-κB p65, NF-κB p65, and β-actin protein expression. (①P<0.001, compared with the db/m group; ②P=0.003, ③P=0.002, compared with the model group; n=3). B. Western blotting analysis of the protein expression levels of WT-1, p-NF-κB p65, NF-κB p65, and β-actin in HPCs. Quantitative analysis of WT-1, p-NF-κB p65, and NF-κB p65. (④P<0.001, compared with the NG group; ⑤P<0.001, compared with the HG group).

Fig 8 Effect of HYP on WT-1 and NF-κB signaling pathway protein expression analyzed by Western blotting