孤独、主观幸福感与衰弱指数因果关系的孟德尔随机化研究

艾克热木·艾尔肯, 陈兴娟, 钮岳岳

Mendelian randomization study of loneliness, subjective well-being, and frailty index

Aikeremu Aierken, Chen Xingjuan, Niu Yueyue

表2 遗传预测孤独感的工具变量

Tab 2 Instrumental variables for genetically predicted loneliness

SNP EA NEA EAF β SE P value F statistics rs6430286 G A 0.58 0.005 0.001 1.44×10-8 32.14 rs74338595 T C 0.71 0.005 0.001 4.82×10-9 34.26 rs4465966 A G 0.43 0.005 0.001 1.44×10-8 32.13 rs171697 C G 0.67 -0.005 0.001 6.81×10-9 33.59 rs2069117 A C 0.37 -0.005 0.001 8.97×10-10 37.54 rs10456089 G A 0.92 0.009 0.002 2.55×10-9 35.50 rs7770860 T C 0.63 -0.005 0.001 1.45×10-8 32.12 rs773020 G A 0.10 -0.009 0.001 5.32×10-9 34.07 rs13291079 T C 0.58 0.005 0.001 9.21×10-11 41.99 rs62085660 C G 0.26 0.005 0.001 4.86×10-9 34.24 rs613872 G T 0.17 -0.008 0.001 5.77×10-14 56.45