孤独、主观幸福感与衰弱指数因果关系的孟德尔随机化研究

艾克热木·艾尔肯, 陈兴娟, 钮岳岳

Mendelian randomization study of loneliness, subjective well-being, and frailty index

Aikeremu Aierken, Chen Xingjuan, Niu Yueyue

表3 遗传预测主观幸福感的工具变量

Tab 3 Instrumental variables for genetically predicted subjective well-being

SNP EA NEA EAF β SE P value F statistics rs10484399 A G 0.916 04 -0.026 0.005 1.99×10-7 27.04 rs10769190 T C 0.197 80 0.018 0.004 6.80×10-6 20.25 rs11073619 T C 0.104 50 0.025 0.005 5.73×10-7 25.00 rs11610143 C G 0.802 20 0.019 0.004 2.03×10-6 22.56 rs12143280 T C 0.944 03 0.038 0.008 2.03×10-6 22.56 rs12298541 A C 0.356 30 0.016 0.003 9.64×10-8 28.44 rs13235506 T G 0.955 22 -0.034 0.007 1.19×10-6 23.59 rs17005492 T C 0.785 40 0.018 0.004 6.80×10-6 20.25 rs2017279 A G 0.679 10 0.016 0.003 9.64×10-8 28.44 rs258668 T C 0.595 10 -0.017 0.003 1.46×10-8 32.11 rs4589952 T C 0.154 90 -0.021 0.004 1.52×10-7 27.56 rs6587766 T C 0.041 04 0.047 0.009 1.77×10-7 27.27 rs707533 A G 0.666 00 0.019 0.003 2.40×10-10 40.11 rs7149000 A G 0.459 00 -0.014 0.003 3.06×10-6 21.78 rs7239568 A C 0.688 40 -0.016 0.003 9.64×10-8 28.44 rs7969982 T C 0.925 37 -0.031 0.006 2.38×10-7 26.69