法托他汀通过靶向SCAP/SREBP通路促进铁死亡及抑制ARID1A缺失型非小细胞肺癌

陈鑫鸿, 张雪, 刘婷, 张淑敏, 马雨鹏, 来佳辉, 章子晗, 池永斌

Fatostatin targets SCAP/SREBP pathway to inhibit ARID1A-deficient non-small cell lung cancer by promoting ferroptosis

Chen Xinhong, Zhang Xue, Liu Ting, Zhang Shumin, Ma Yupeng, Lai Jiahui, Zhang Zihan, Chi Yongbin

图1 ARID1A缺失对NSCLC 细胞脂质和胆固醇合成的影响 Note： A. Efficient knockout of ARID1A protein in A549 cells confirmed by Western blotting. B.Quantification of ARID1A protein expression in the KO group and WT group. C. GO enrichment analysis for the joint functional annotation of transcriptomic and proteomic data. D. KEGG pathway enrichment analysis of DEGs identified in the transcriptomic dataset. E.Volcano plot depicting differential gene expression between the WT group and KO group. F. KEGG pathway enrichment analysis of differentially expressed proteins identified in the proteomic dataset. G. Volcano plot depicting differential protein expression between the WT group and KO group.

Fig 1 Effect of ARID1A loss on lipid and cholesterol synthesis in NSCLC cells