脂质代谢昼夜节律机制及其对脑卒中发病的影响综述

李北, 李婧晨, 郭熙朗, 於原思渡, 罗亦弘, 胡琴, 高丽

Review of circadian rhythm mechanism of lipid metabolism and its impact on the incidence of stroke

Li Bei, Li Jingchen, Guo Xilang, Yu Yuansidu, Luo Yihong, Hu Qin, Gao Li

图2 外周组织脂质代谢的昼夜节律分子机制 Note： SCN—suprachiasmatic nucleus; CLOCK—circadian locomotor output cycles kaput; Per1/2/3—period circadian regulator 1/2/3; INSIG—insulin induced gene; DGAT-2—diacylglycerol O-acyltransferase 2; ACAD11—acyl-CoA dehydrogenase family member 11; Cry—cryptochrome; Pparα—peroxisome proliferator-activated receptor α; ATGL—adipose triglyceride lipase; HSL—hormone-sensitive lipase; SREBP1c—sterol regulatory element-binding protein 1c.

Fig 2 Molecular mechanisms of circadian rhythm regulation in peripheral lipid metabolism