去泛素化酶USP38通过稳定RBM14促进胃癌进展的机制研究

陈赟琪, 那迪娜·帕尔哈提, 张鹏善, 黄陈

Deubiquitinase USP38 promotes gastric cancer progression by stabilizing RBM14

Chen Yunqi, Paerhati Nadina, Zhang Pengshan, Huang Chen

图1 USP38在胃癌组织及细胞中的表达模式及其对预后的影响 Note： A. Expression of USP38 mRNAin gastric cancer (n=375) and normal (n=32) tissues from the TCGA-stomach adenocarcinoma (STAD) database. B. USP38 mRNA expression in 50 paired gastric cancer and adjacent normal tissues determined by qPCR. C. Detection of USP38 expression in gastric cancer (n=4) and adjacent normal (n=4) tissues detected by Western blotting. The numbers indicate relative protein expression levels. D. qPCR analysis of USP38 mRNA expression in different gastric cancer cell lines, compared with human normal gastric mucosal cells. E. Kaplan-Meier survival curves of gastric cancer patients (n=856) from GEO database according to USP38 expression.

Fig 1 Expression of USP38 in gastric cancer tissues and cells and its impact on prognosis