去泛素化酶USP38通过稳定RBM14促进胃癌进展的机制研究

陈赟琪, 那迪娜·帕尔哈提, 张鹏善, 黄陈

Deubiquitinase USP38 promotes gastric cancer progression by stabilizing RBM14

Chen Yunqi, Paerhati Nadina, Zhang Pengshan, Huang Chen

图6 USP38对RBM14蛋白的稳定作用 Note： A. Correlation analysis showing a positive association between USP38 and RBM14 mRNA expression in the TCGA-STAD database. B. RBM14 expression in gastric cancer tissues (n=375) and normal tissues (n=32) in TCGA database. C. Kaplan-Meier survival curves associating high RBM14 expression with poor prognosis in gastric cancer patients (n=631) in GEO database. D. Western blotting analysis of RBM14 protein levels following USP38 knockdown with or without MG132 treatment. Comparison of RBM14 protein levels: shUSP38vs shNC and shUSP38vs shUSP38+MG132. E. CHX chase assay showing accelerated RBM14 protein degradation upon USP38 knockdown (shUSP38vs shNC). Data are presented as mean±SD.

Fig 6 Stabilizing effect of USP38 on RBM14 protein