上海交通大学学报(医学版)

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钙整合素结合蛋白研究进展

李 明,江基尧,殷玉华   

  1. 上海交通大学 医学院附属仁济医院神经外科, 上海 200127
  • 出版日期:2013-09-28 发布日期:2013-09-29
  • 通讯作者: 殷玉华, 电子信箱: yyhneuron@163.com。
  • 作者简介:李 明(1987—), 男, 硕士生; 电子信箱: limingneuron@163.com。
  • 基金资助:

    国家自然科学基金(81000829);上海市科委基金(08JC1414800)

Research progress of calcium- and integrin-binding proteins

LI Ming, JIANG Ji-yao, YIN Yu-hua   

  1. Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2013-09-28 Published:2013-09-29
  • Supported by:
    National Natural Science Foundation of China, 81000829; Shanghai Science and Technology Committee Foundation, 08JC1414800

摘要:

近年研究表明,钙整合素结合蛋白(CIB)在多种组织广泛表达并参与各种不同的细胞生物学过程。CIB可与许多蛋白发生相互作用,参与DNA损伤修复、细胞周期调节、细胞凋亡、神经系统早期发育、神经元可塑性、神经退行性疾病等病理生理过程,因此对CIB的深入研究将为疾病的治疗提供新的思路。文章对CIB的研究进展进行综述。

关键词: 钙整合素结合蛋白, 结构特点, 生物学功能

Abstract:

Recent researches show that calcium- and integrin-binding proteins (CIB) express in lots of tissues and participate in a wide variety of different cell biological processes. CIB can interact with multitudinous proteins, and may involve in the DNA damage response, cell cycle, cell apoptosis, embryogenesis, neuronal plasticity and neurodegenerative diseases. So in-depth research on CIB may provide new ideas for the treatment of diseases. The research progress of CIB is reviewed in this paper.

Key words: calcium- and integrin-binding proteins, structure feature, biological function