上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (1): 70-.

• 论著（临床研究） • 上一篇    下一篇

急性闭合性颅脑损伤患者血清Nogo-A蛋白的变化

林在楷, 田恒力, 吴炳山, 陈世文, 郭 衍, 王 敢, 陈 浩, 徐 涛   

  1. 上海交通大学 第六人民医院神经外科, 上海 200233
  • 出版日期:2010-01-26 发布日期:2010-01-26
  • 通讯作者: 田恒力, 电子信箱: tianhengli1964@yahoo.com.cn。
  • 作者简介:林在楷（1982—）, 男, 硕士生；电子信箱: linzaikai@126.com。
  • 基金资助:

    上海市科委基金(03ZR14059)

Change of serum Nogo-A protein in patients with acute closed brain injury

LIN Zai-kai, TIAN Heng-li, WU Bing-shan, CHEN Shi-wen, GUO Yan, WANG Gan, CHEN Hao, XU Tao   

  1. Department of Neurosurgery, The Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2010-01-26 Published:2010-01-26
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 03ZR14059

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摘要：

目的 探讨急性闭合性颅脑损伤患者血清Nogo-A蛋白的变化及其与颅脑创伤程度和预后的关系。方法 选择31例急性闭合性颅脑损伤患者，分别于伤后第1、3、5天采集静脉血2 mL，ELISA法测定血清Nogo-A蛋白质量浓度；根据格拉斯哥昏迷评分（GCS），将患者分为轻度颅脑损伤组（n=7）、中度颅脑损伤组（n=10）和重度颅脑损伤组（n=14）；根据格拉斯哥预后评分（GOS），分为预后良好组（n=23）和预后不良组（n=8）。以20名健康成人作为对照组。结果 重、中、轻度颅脑损伤组伤后第1、3、5天血清Nogo-A蛋白质量浓度均显著高于对照组（P<0.01）。中、重度颅脑损伤组患者伤后第1、3、5天血清Nogo-A蛋白质量浓度均高于相同时间点的轻度颅脑损伤组患者（P<0.05，P<0.01）。预后不良组患者伤后第1、3、5天血清Nogo-A蛋白质量浓度显著高于相同时间点的预后良好组患者（P<0.01）。结论 颅脑损伤后急性期患者血清Nogo-A蛋白水平显著升高，且与损伤程度及预后有一定关系。

关键词: Nogo-A, 颅脑创伤, 轴突再生, 预后

Abstract:

Objective To investigate the change of serum Nogo-A protein in patients with acute closed brain injury, and explore its relationship with the severity of neuronal damage and prognosis. Methods Thirty-one patients with acute closed brain injury were enrolled. Venous blood samples (2 mL) were obtained 1, 3 and 5 d after injury. Serum concentrations of Nogo-A protein were determined by ELISA. Patients were divided into mild （n=7）, moderate （n=10） and severe （n=14） injury groups according to Glasgow coma score (GCS), and were divided into favorable prognosis (n=23) and poor prognosis (n=8) groups according to Glasgow outcome score (GOS). Another 20 healthy adults were served as controls. Results The mass concentrations of serum Nogo-A protein in mild, moderate and severe injury groups 1, 3, 5 d after injury were significantly higher than those in control group (P<0.01), and the mass concentrations of serum Nogo-A protein in moderate and severe injury groups 1, 3, 5 d after injury were significantly higher than those in mild injury group （P<0.05, P<0.01）. The mass concentrations of serum Nogo-A protein 1, 3, 5 d after injury were significantly higher in poor prognosis group than those in favourable prognosis group (P<0.01). Conclusion Serum Nogo-A protein level significantly increases after brain injury, and is related to the degree of injury and prognosis.

Key words: Nogo-A, brain injury, axonal regeneration, prognosis