›› 2013, Vol. 33 ›› Issue (6): 878-.doi: 10.3969/j.issn.1674-8115.2013.06.036

• Review • Previous Articles     Next Articles

Cellular proliferation regulations by tumor suppressor gene PTEN

XIONG Zhong1, CHEN Guo-qiang1,2   

  1. 1.Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; 2.Department of Pathophysiology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2013-06-28 Published:2013-06-28


Phosphatase and tensin homolog deleted on chromosome ten (PTEN), one of the mostly investigated tumor suppressor genes, has a close correlation with tumorigenesis. The activation of PI3K-AKT pathway caused by abnormal PTEN is one of the major mechanisms underlying tumor occurrence. Therefore, PTEN regulation is important for uncovering new mechanisms of tumor occurrence and establishing novel therapeutic strategies. The cellular PTEN regulations including transcriptional regulation, post-transcriptional modulation, post-translation modification and protein-protein interaction are reviewed in this paper.

Key words: tumor suppressor gene, phosphatase and tensin homolog deleted on chromosome ten, cellular regulation