Abstract:

Objective To explore the diagnosis and the treatment options of granulocytic sarcoma (GS). Methods The clinical manifestations, classification of pathological characteristics, diagnosis and treatment of 9 cases with GS were retrospectively analyzed. Results All of the 9 patients presented with lymphadenopathy and soft tissue mass as first symptoms. The pathological feature of GS was the differentiation of granulocytic and medium size mature eosinophils. The majority of GS patients exhibited positive immuno-histological results of myeloperoxidase, lysozyme, CD43, CD34, CD56 and CD15. The therapeutic options included local resection, radiation therapy and systemic chemotherapy with regimen of acute myeloid leukemia (AML). Conclusion The diagnosis of GS depends on the pathologic feature, immunohistochemical characteristics of tissues, morphology, immunology, cytogenetics and molecular biology examinations of bone marrow, in order to define the type of GS (isolated type or AML). The principle treatment options of GS are local resection, radiation therapy and systemic chemotherapy.

Key words: granulocytic sarcoma, diagnosis, therapy