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Effects of distribution of AMPA receptors on incidence of Parkinson disease and dyskinesia

GAN Jing, QI Chen, ZHANG Su-fang, LIU Zhen-guo   

  1. Department of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2015-03-28 Published:2015-03-26
  • Supported by:

    National Natural Science Foundation of China, 81171203, 81200871, 81400925; Project of Science and Technology Commission of Shanghai Municipality, 12XD1403800

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Abstract:

Objective To observe changes of the subcellular distribution of subtypes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors in the striatum of Parkinson disease (PD) and dyskinesia [levodopa-induced dyskinesia (LID)] rat model. Methods Neurotoxin 6-hydroxydoapmine (6-OHDA) was used to establish the PD rat model. PD rats were intraperitoneally injected with levodopa to establish the LID rat model. The surface receptor cross-linking assay was adopted and changes of levels of AMPA receptor subtypes at different locations of surface pools and intracellular pools of striatal neurons were detected by the Western blotting. Results The subcellular distribution of subtypes of AMPA receptors in the striatum of PD rats showed no changes. AMPA total protein and the distribution of AMPA in surface pools and intracellular pools of the striatum of LID rats were not significantly affected by the chronic induction of levodopa. Conclusion Changes of the distribution of AMPA receptors have no significant effect on the incidence of PD or LID.

Key words: Parkinson disease, dyskinesia, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor, striatum