Abstract:

Objective  To explore the therapeutic effect and prognosis of treating patients with interstitial cystitis by intravesical hyaluronic acid instillation and heparin-lidocaine instillation. Methods  A total of 24 patients with interstitial cystitis who were admitted in Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine from February 2013 to April 2015 were selected. The patients, randomly divided into hyaluronic acid (HA) group and heparin sodium-lidocaine (HL) group, underwent the intravesical chemotherapy after bladder hydrodistention, and were followed up every 3 months for 12 months. Frequency of daily voiding and vision analogue scale (VAS) of pelvic pain of two groups before and after treatment were compared. Results  All 24 patients completed the follow-up and no obvious complications of intravesical instillation were recorded during the course of treatment. For the remission rate, only the complete remission rates of two groups by the end of 12 months were significantly different (HA group was 4/13 and HL group was 2/11, P<0.05). For symptom control, the urinary frequency, urinary urgency, and subabdominal pain of both groups were significantly alleviated at the early phase of treatment. But at the time point of 12 months after instillation, the differences of frequency of daily voiding and VAS of HL group before and after treatment were not statistically significant (P>0.05), while the therapeutic effect of the HA group remained. The difference between two groups was statistically different (P<0.05). Conclusion  The effect of treating interstitial cystitis by hyaluronic acid intravesical instillation lasts 12 months in terms of symptom control and is better than that of treating interstitial cystitis by heparin sodium-lidocaine intravesical instillation.

Key words: interstitial cystitis, hyaluronic acid, bladder hydrodistention