›› 2016, Vol. 36 ›› Issue (08): 1121-.doi: 10.3969/j.issn.1674-8115.2016.08.003

• Original article (Basic research) • Previous Articles     Next Articles

Association between cancer relapse and p53 hotspot mutations

WANG Huan-bin, XU Jie   

  1. Department of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai 200001, China

  • Online:2016-08-29 Published:2016-08-31
  • Supported by:

    National Natural Science Foundation of China, 81572326, 81322036, 30971330, 31371420, 81320108024, 81000861, 81421001, 81272383; Top-Notch Young Talents Program of China, ZTZ2015-48; National Key Technology Support Program, 2015BAI13B07; Shanghai Municipal Education Commission–Gaofeng Clinical Medicine Grant Support, 20152514

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Abstract:

Objective · To investigate the association between different p53 mutations and cancer relapse. Methods · Cancer patients in The Cancer Genome Atlas (TCGA) and MSKCC bladder cancer dataset were stratified according to TP53 genotypes and compared for the relapse-free survival (RFS). Results · Missense mutations at R248 and R282 positions were significantly associated with shorter RFS (P<0.05, HR>2). Although increased hazard ratios were also found for hotspot mutations at R175, G245, and R273 positions, no statistical significance was reached. When mutations of the same type were considered as a cluster, hotspot mutations (but not all missense mutations) were associated with shorter RFS. Frameshift mutations and nonsense mutations had similar effects on RFS. Conclusion · Not all p53 hotspot mutations are associated with shorter RFS, suggesting that p53 hotspot mutations should be differentially treated as different tumor markers.
 

Key words: cancer relapse, mutant p53, gain of function