›› 2017, Vol. 37 ›› Issue (9): 1287-.doi: 10.3969/j.issn.1674-8115.2017.09.017?

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Progress in genetics of autoimmune hepatitis#br#

WEI Yi-ran, MA Xiong, TANG Ru-qi   

  1. Shanghai Institute of Digestive Disease; Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China
  • Online:2017-09-28 Published:2017-10-10
  • Supported by:
     National Natural Science Foundation of China, 81400608; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20161311

Abstract: Autoimmune hepatitis (AIH) is an autoimmune liver disorder characterized by chronic inflammation of liver. Although the etiology of AIH remains obscure, genetic and environmental factors may contribute to the development of AIH. In the past years, investigators have attempted to uncover the genetic architecture of AIH. Multiple genetic loci have been reported to be associated with AIH, in which human leukocyte antigen (HLA) alleles were strongly associated with disease onset and clinical manifestations for decades. A recent genome wide association study identified that two loci (SH2B3 and CARD10) increased susceptibility of AIH, in addition to the HLA loci. The genetic study is aiming to help to elucidate the genetic pathogenesis
 for AIH.

Key words: autoimmune hepatitis, human leukocyte antigen, genome-wide association study