JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (06): 719-727.doi: 10.3969/j.issn.1674-8115.2020.06.004

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Evaluation of physical and neurocognitive development of infants conceived from frozen embryo transfer

DONG Ze-han*, WU Yan-ting*, LIU Han, WANG Yin-yu, HUANG He-feng   

  1. Shanghai Key Laboratory of Embryo Original Diseases, Department of Assisted Reproduction, The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2020-06-28 Published:2020-06-28
  • Supported by:
    National Key R&D Program of China (2016YFC1000203); National Natural Science Foundation of China (81661128010); Project of Shanghai Municipal Health Commission (201840210); Project of Shanghai Shenkang Hospital Development Center (SHDC12018X17); Innovative Research Team of High-level Local Universities in Shanghai (SSMU-ZLCX20180400).

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Abstract: Objective · To evaluate the physical and neurocognitive development of infants conceived from frozen embryo transfer (FET). Methods · Two hundred and forty-eight infants (1.5-4 years old) conceived from FET and natural conception (NC) were recruited as the follow-up cohort of FET offspring, and their physical and neurocognitive development were followed up and evaluated. Multiple Logistic regression analysis was used to assess the potential risk of cognitive retardation in FET offspring. Results · There was no significant difference in composition ratio of Z score for height, weight and body mass index between the FET group and the NC control group. Multiple Logistic regression analysis showed that compared with the NC control group, the risk of neurocognitive development abnormalities and retardation was higher in the FET group, especially in fine motor (OR=3.01, 95%CI 1.48-6.11) and social development domains (OR=3.76, 95%CI 1.63-8.69); and in the FET group, the social development risk of female infants was higher than that of male infants. Conclusion · FET may exert a negative impact on the early neurocognitive development of infants.

Key words: frozen embryo transfer (FET), in vitro fertilization (IVF), physical growth, neurocognitive development

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