›› 2010, Vol. 30 ›› Issue (5): 500-.

• Monographic report (Adrenal diseases) • Previous Articles     Next Articles

One case report of adrenocorticotrophic hormone independent macronodular adrenal hyperplasia

ZHOU Wei-wei1, JIANG Lei1, SU Ting-wei1, JIANG Yi-ran1, WANG Yi-feng1, TANG Xin1, YU Fang1, ZHU Yu2, SUN Fu-kang2, FANG Wen-qiang3, JIN Xiao-long4, NING Guang1, WANG Wei-qing1   

  1. 1.Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, 2.Department of Urology, 3.Department of Radiology, 4.Department of Pathology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2010-05-25 Published:2010-05-28

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Abstract:

Primary adrenal causes contribute to 15% to 20% of Cushing's syndrome, and bilateral adrenal hyperplasia was found in 10% of patients with Cushing's syndrome. Cortisol secretion in adrenal Cushing's syndrome can be regulated by the aberrant adrenal expression of receptors for gastric inhibitory polypeptide, vasopressin, catecholamines, luteinizing hormone/human choriogonadotropin (LH/hCG) and serotonin. In this paper, a case of Cushing's syndrome caused by adrenocorticotrophic hormone-independent macronodular adrenal hyperplasia is reported.

Key words: Cushing´s syndrome, adrenocorticotrophic hormone independent macronodular adrenal hyperplasia, aberrant membrane receptors