Research progress of effects of PDE5 inhibitors on sperm motility and fertilizing capacity

doi:10.3969/j.issn.1674-8115.2012.08.011

›› 2012, Vol. 32 ›› Issue (8): 1010-.doi: 10.3969/j.issn.1674-8115.2012.08.011

• Monographic report (Infertility and assisted reproductive technology) • Previous Articles Next Articles

Research progress of effects of PDE5 inhibitors on sperm motility and fertilizing capacity

LU Ke-min, LU Hui, LI Zheng

Department of Urology, Shanghai Human Sperm Bank, Sperm Development and Genetics Laboratory, Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China

Online:2012-08-28 Published:2012-08-29
Supported by:
Shanghai Science and Technology Committee Foundation, 10JC1409900

Abstract

Abstract:

Phosphodiesterase-5 (PDE5) inhibitors are commonly used in the treatment of penile erectile dysfunction (ED). Recent studies have revealed that PDE5 inhibitors have impact on sperm motility and fertilizing capacity, and can significantly improve sperm motility in the appropriate concentration. The effects of PDE5 inhibitors on sperm motility and fertilizing capacity are reviewed in this paper.

Key words: phosphodiesterase-5 inhibitor, spermatozoa, motility, fertilization

LU Ke-min, LU Hui, LI Zheng. Research progress of effects of PDE5 inhibitors on sperm motility and fertilizing capacity[J]. , 2012, 32(8): 1010-.

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Research progress of effects of PDE5 inhibitors on sperm motility and fertilizing capacity

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