Abstract:

Shortage of donors has been remaining a major obstacle in organ transplantation around the world for a long time. In the current study, a new pattern of liver transplantation, named partial liver transplantation, was established as a solution for deficiency of hepatic donor and a serial of original results has been achieved. After review and comparison with similar domestic and overseas investigations, some innovations and discoveries were found in this method. ①Establishment of the selection criteria of graft and the reconstruction pattern of right hemi hepatic grafts venous drainage. ②In living donor liver transplantation, the safety and necessity of using right hemi hepatic graft with middle hepatic vein in right hemi hepatic graft were determined by comparing the operational results with or without middle hepatic vein. ③This is the first time in China that split liver transplantation was adopted for the treatment of terminal liver diseases. The largest number of cases has been maintained in a single domestic transplantation center. ④It is also the first in China that one case of living donor liver transplantation using dual grafts was carried out successfully with non-identical blood types between donor and recipient. This modus operandi could provide recipient with a greater weight of liver graft and maximum safety of donor as well. ⑤The pharmacokinetics and pharmacodynamics of mycophenolic acid in Chinese liver transplant recipients were reported for the first time in this report. By monitoring of the full exposure of mycophenolic acid, abbreviated sampling strategy was adopted to determine the area under the curve. In addition, the pharmacokinetics of mycophenolic acid and its metabolites were compared between living donor liver transplant recipients and deceased donor liver transplant recipients. The research achievement has been awarded the second prize of National Science and Technology Progress.

Key words: multimodality, liver transplantation, donor, mycophenolic acid