Abstract:

Scar, vascular anomalies and lymphedema are the common diseases that are difficult to treat, which severely affect patients´ psychological and physical fitness. Therefore, further defining the disease mechanism and improving the diagnosis and therapeutic efficiency are the important topics of this area. In this project, our group has: ①revealed the role of keloid stem cells, drug resistance and GDF-9 differentiation in keloid development; ②established low dose chemotherapy of keloid with increased cure rate and reduced recurrence rate; ③established engineered epidermis to treat wound bed to inhibit scar formation; ④established diagnosis and therapy system in infantile hemangioma; ⑤established clinical classification of port wine stains; ⑥established diagnosis and therapy of venous malformations; ⑦established diagnosis and therapy methods for arteriovenous malformations; ⑧preliminarily defined the molecular mechanism of lymphedema; ⑨established MRI diagnosis for lymphedema; ⑩development of specialized traditional Chinese medicine for lymphedema.

Key words: scarring, hemangioma, lymphedema