›› 2012, Vol. 32 ›› Issue (10): 1378-.doi: 10.3969/j.issn.1674-8115.2012.10.022

• Review • Previous Articles     Next Articles

Research progress of fibroblast growth factor 19 with glucose, lipid and protein metabolism

NI Jie, BAO Yu-qian   

  1. Department of Endocrinology and Metabolism, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China
  • Online:2012-10-28 Published:2012-11-05
  • Supported by:

    National Basic Research Program of China, “973” Program, 2012CB524906；National Natural Science Foundation of China, 81170788

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Abstract:

Fibroblast growth factor 19 (FGF19) is one of the members of the fibroblast growth factor family, and has been shown to regulate the bile acid balance. Recent studies have revealed that FGF19 plays an important role in glucose, lipid and protein metabolism, which could induce glycogen and protein synthesis, suppress gluconeogenesis and triglyceride and cholesterol synthesis in liver. These new findings of FGF19 may pave a new way for the treatment of metabolic diseases such as diabetes mellitus.

Key words: fibroblast growth factor 19, bile acid, glucose and lipid metabolism, protein synthesis