Age at natural menopause (ANM) is a complex trait which is determined by genes and environment, and the genetic effects are prominent. Early or delayed menopause is associated with female-related diseases. Exploring genetic factors of ANM can help to predict the potential health problems of postmenopausal women, and may provide appropriate health guidance. It has been found by genome-wide association studies and candidate gene association studies that several genes are associated with ANM. The research progress of candidate genes of ANM is reviewed in this paper.