Objective To investigate the feasibility, efficacy and safety of interventional therapy for pulmonary sequestration. Methods The clinical data of 6 patients with pulmonary sequestration undergoing interventional therapy were retrospectively analysed. Pulmonary arteriography and aortography were performed during the treatment. Embolization using Amplatzer Plug was conducted in patients with single aberrant artery and diameter of proximal blood vessel < 12 mm, and membrane tectoria stent sequestration was carried out in those with multiple aberrant arteries and/or diameter of proximal blood vessel > 12 mm. Results Pulmonary arteriography revealed the absence of bottom left pulmonary artery in all the 6 patients. Aortography demonstrated 8 aberrant arteries originating from descending aorta. The interventional therapy was successfully performed in all the 6 patients. Patients were followed up for 1 to 5 years, the symptom of haemoptysis disappeared, and chest enhancement CT indicated that the bottom left lung ischemically shrinked or vanished. Conclusion Interventional therapy is safe and effective for pulmonary sequestration.