Journal of Shanghai Jiao Tong University (Medical Science) >

2013 , Vol. 33 >Issue 7: 990

DOI: https://doi.org/10.3969/j.issn.1674-8115.2013.07.019

Original article (Clinical research)

Serum transforming growth factor-β levels in patients with diabetic retinopathy

  • LUO Da-wei ,
  • ZHENG Zhi ,
  • LIU Kun ,
  • et al
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  • Department of Ophthalmology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China

Online published: 2013-08-22

Supported by

Shanghai Key Laboratory for Ocular Fundus Disease Foundation, 07Z22911

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Abstract

Objective To investigate the serum transforming growth factor-β (TGF-β) levels in patients with diabetic retinopathy  (DR). Methods Seventy-two patients with diabetes were selected, including 15 patients with proliferative diabetic retinopathy (PDR group), 32 patients with non-proliferative diabetic retinopathy (NPDR group) and 25 patients with non-diabetic retinopathy group (NDR group). Besides, 45 healthy people were served as normal control group. The serum TGF-β levels were detected by ELISA. Results Serum TGF-β levels in groups with diabetes were significantly higher than that in normal control group (P<0.01). Serum TGF-β level in PDR group was significantly higher than those in NPDR group and NDR group (P<0.05). Conclusion Serum TGF-β level is associated with the severity of diabetic retinopathy.

Key words： diabetic retinopathy; transforming growth factor-β; proliferative diabetic retinopathy

Cite this article

LUO Da-wei , ZHENG Zhi , LIU Kun , et al . Serum transforming growth factor-β levels in patients with diabetic retinopathy[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2013 , 33(7) : 990 . DOI: 10.3969/j.issn.1674-8115.2013.07.019

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