Impact of glutathione system on coronary heart diseases
Online published: 2013-09-29
Objective To investigate the impact of glutathione system on coronary heart disease. Methods One hundred and seventy-nine patients undergoing coronary angiography were selected, and were divided into elder group (≥60 years old, n=102) and non-elder group (<60 years old, n=77). The blood biochemical parameters were examined, and the activity of glutathione peroxidase (GSH-Px), glutathione (GSH) and glutathione reductase (GR) was detected. The severity of coronary atherosclerosis was determined by Gensini score system based on the findings of coronary angiography. Results There was no significant difference in blood biochemical parameters between two groups (P>0.05). The plasma activity of GSH, GSH-Px and GR in elder group was significantly lower than that in non-elder group (P<0.05). After adjustment for age, the plasma activity of GSH, GSH-Px and GR was significantly negatively related to Gensini scores (r=-0.721, -0.743 and -0.724; P<0.001). Based on the quartile of Gensini scores, with the increase of Gensini scores, the activity of GSH, GSH-Px and GR decreased gradually (P<0.001). Multiple linear regression analysis indicated that the activity of GSH-Px had the greatest impact on Gensini scores. Conclusion With the age increase, the plasma activity of GSH, GSH-Px and GR significantly decreases, and is negatively related to the severity of coronary artery stenosis, especially for GSH-Px.
YANG Hui , ZHAO Ya-jie , YU Qiang , et al . Impact of glutathione system on coronary heart diseases[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2013 , 33(9) : 1259 . DOI: 10.3969/j.issn.1674-8115.2013.09.015
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