Review

Research progress of related proteins in signaling pathway of integrin αⅡbβ3

  • LI Yi-ting ,
  • XU Yang ,
  • CAI Zhen-xi ,
  • et al
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  • Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

Online published: 2013-09-29

Supported by

National Innovation Program for Undergraduates, 20110248071

Abstract

Integrin αⅡbβ3 plays a pivotal role in platelet activation by interacting with ligands and mediating the signal transduction. After various agonists bind to their acceptors on platelets, the inside-out signaling develops, then the outside-in signaling happens. Talin, kindlin and Src, which are important signaling proteins involved in these progresses, have been intensively studied. Talin and kindlin are essential in inside-out signaling, while Src is important in outside-in signaling. This review focuses on the research progress of talin, kindlin and Src.

Cite this article

LI Yi-ting , XU Yang , CAI Zhen-xi , et al . Research progress of related proteins in signaling pathway of integrin αⅡbβ3[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2013 , 33(9) : 1311 . DOI: 10.3969/j.issn.1674-8115.2013.09.026

Outlines

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