Objective To investigate the effects of integration of rehabilitation training into chronic disease management practice on the clinical symptoms and economic burden of patients with early Parkinson's disease (PD). Methods Forty patients with early PD were included into chronic disease management practice, and were randomly divided into control group (n=20) and rehabilitation training group (n=20). Unified Parkinson's disease rating scale (UPDRS) Ⅲ was employed to evaluate the clinical symptoms before and 3 months after chronic disease management, and the economic costs 3 months before chronic disease management and 3 months after chronic disease management were calculated. Results The implementation of chronic disease management significantly improved the clinical symptoms (P<0.01), and reduced the living expenses, lost incomes and total expenses in two groups (P<0.01). Compared with control group, the clinical symptoms were significantly improved (P<0.05), and the living expenses, lost incomes and total expenses were significantly reduced in rehabilitation training group (P<0.05). Conclusion Rehabilitation training can significantly improve the clinical symptoms and reduce the economic burden of patients with PD, and should be integrated into the chronic disease management practice of patients with early PD.