Objective To construct the longitudinal regional hospital group feasibility evaluation index system with Xinjiang Production and Construction Corps as example. Methods The construction principle of longitudinal regional hospital group feasibility evaluation index system was established, the theory frame was designed through literature review and focus group interview, and hospital group feasibility evaluation index system in Xinjiang Production and Construction Corps was formed with Delphi method. Results Review of 20 literatures indicated that strategic analysis tools were widely employed in the evaluation of feasibility of hospital group. Focus group interview revealed that monopoly, diseconomies of scale, operation and management of primary health care institutions were potential problems for hospital group. Four primary indicators (regional outer environment, core hospital inner environment, member hospital inner environment and cooperation condition), 27 secondary indicators, 49 tertiary indicators and their weights were finally determined after Delphi method. Conclusion Construction of hospital group feasibility evaluation index system in Xinjiang Production and Construction Corps provides a measurement tool for evaluation of feasibility of hospital group.