Review

Advances of protein kinase C beta and diabetic nephropathy

  • ZHAO Ming-ming ,
  • LIU Li-mei
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  • Shanghai Diabetes Institute,Department of Endocrinology and Metabolism, the Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

Online published: 2014-05-13

Supported by

National Natural Science Foundation of China, 81270876,30771022,30971384;Outstanding Academic Leaders Foundation of Science and Technology Commission of Shanghai Municipality,10XD1403400

Abstract

Two isoforms of protein kinase C (PKC), i.e. PKC-βI and -βⅡ, which are encoded by the PRKCB1 gene, play important roles in the development and progression of diabetic nephropathy through the PKC signaling pathway. PKC-β inhibitor can reduce the thickness of glomerular basement membrane and microalbuminuria to protect the renal functions of diabetes patients. Polymorphisms and variants of PRKCB1 gene are relevant to increasing the risk of diabetic nephropathy and end stage renal disease by affecting its transcriptional activity, increasing insulin resistance, and promoting endothelial oxidative stress. This paper reviews the research progresses on the relationship between PKC-β and diabetic nephropathy.

Cite this article

ZHAO Ming-ming , LIU Li-mei . Advances of protein kinase C beta and diabetic nephropathy[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2014 , 34(4) : 551 . DOI: 10.3969/j.issn.1674-8115.2014.04.030

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