Neogenin is a member of the DCC (deleted in colorectal cancer) family which involves in many physiological and pathological processes such as body homeostasis, tissue formation, angiogenesis, iron metabolism, immunoregulation, cell differentiation, proliferation, migration, and apoptosis through interacting with different ligands such as neuronal guidance cues (netrin) and repulsive guidance molecule(RGM). However, research on the osteogenesis modulated by neogenin is still in its infancy. This paper reviews the research progresses of neogenin, which involve its molecular characteristics, distribution, physiological functions, and roles in modulating osteogenesis through BMP signaling pathway.