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Correlation between 11β-hydroxysteroid dehydrogenase and metabolic syndrome

  • RUAN Li-li ,
  • ZOU Chao-chun
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  • 1.Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; 2.Department of Pediatrics, the Second People's Hospital, Hangzhou 310015, China

Online published: 2014-06-30

Supported by

Zhejiang province Science and Technology Innovation Team Focused on Independent Projects,2010R50045

Abstract

Metabolic syndrome (MetS) is a pathological condition of disorders of several metabolic components and a risk factor of causing cardiovascular diseases and diabetes. Dysregulation of glucocorticoid is an important feature of MetS. 11β-hydroxysteroid dehydrogenase (11β-HSD) of the body mainly converts the active glucocorticoid to its inactive precursor and regulates the concentration of local glucocorticoid. 11β-HSD involves pathophysiologic processes of MetS such as insulin resistance, obesity, type 2 diabetes, and hypertension. The application of 11β-HSD1 inhibitors may provide new methods for treating MetS.

Cite this article

RUAN Li-li , ZOU Chao-chun . Correlation between 11β-hydroxysteroid dehydrogenase and metabolic syndrome[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2014 , 34(6) : 924 . DOI: 10.3969/j.issn.1674-8115.2014.06.032

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