Review

Advances of preventive and therapeutic strategies for acquired heterotopic ossification

  • GAO You-shui ,
  • SUN Yu-qiang ,
  • ZHANG Chang-qing
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  • Department of Orthopedic Surgery, the Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

Online published: 2014-06-30

Abstract

Acquired heterotopic ossification (AHO) is a common complication following severe trauma, burning, cerebrospinal injuries, and artificial joint replacements and often leads to unsatisfactory prognosis. Although non-steroidal anti-inflammatory drugs (NSAIDs) and radiotherapy have been the classical methods for prevention and treatment of AHO, their effectiveness is doubted in recent years and the systemic complications induced by radiation therapy (RT) cannot be ignored. Therefore, new methods for the effective prevention of AHO have to be developed. The incidence and severity of AHO can be effectively reduced through analyzing risk factors, revealing preventive mechanisms of new NSAIDs and RT, and combining with surgical interventions. The deep insight into the mechanism of AHO has resulted in targeted preventive and therapeutic methods, especially retinoic acid receptor target drugs that may bring revolutionary changes.

Cite this article

GAO You-shui , SUN Yu-qiang , ZHANG Chang-qing . Advances of preventive and therapeutic strategies for acquired heterotopic ossification[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2014 , 34(6) : 934 . DOI: 10.3969/j.issn.1674-8115.2014.06.034

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