Clinicopathological significance of expressions of p27kip1 and Ki-67 in primary central nervous system germ cell tumors
Online published: 2014-12-30
Supported by
Foundation of Science and Technology Commission of Shanghai Municipality,134119a9502,12DZ2260600
Objective To investigate the clinicopathological significance of expressions of tumor suppressor gene p27kip1 and expression of cyclin Ki-67 in primary central nervous system germ cell tumors (CNSGCTs). Methods The expressions of p27kip1 and Ki-67 in tissues of 28 cases of primary CNSGCTs were detected by immunohistochemical method and Ki-67 labeling index (Ki-67 LI) was calculated. Results Among 28 cases of primary CNSGCTs, the p27kip1 expression of 17 cases (60.7%) was high, including 5 cases of mature teratomas, 10 cases of germinomas, 1 case of embryonal carcinoma, and 1 case of mixed GCT; and the p27kip1 expression of 11 cases (39.3%) was low, including 8 cases of germinomas, 1 case of immature teratoma, 1 case of choriocarcinoma, and 1 case of mixed GCT. The Ki-67 LI of 13 cases (46.4%) was higher than 50%; Ki-67 LI of 9 cases (32.1%) was 25%-50%; and Ki-67 LI of 6 cases (21.4%) was lower than 25%. The expression of p27kip1 and Ki-67 LI correlated with the histological types of CNSGCTs. The expression of p27kip1 did not correlate with sex, age, size of tumor, location, recurrence, prognosis, or Ki-67 LI (P>0.05). Conclusion The expression of p27kip1 is low in malignant primary CNSGCTs, which suggests that p27kip1 may involve in the formation and development of germ cell tumor by down-regulating the control point for transiting from G1 to S phase.
GAO Yu-ping , JIANG Ji-yao , LIU Qiang . Clinicopathological significance of expressions of p27kip1 and Ki-67 in primary central nervous system germ cell tumors[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2014 , 34(12) : 1767 . DOI: 11.3969/j.issn.1674-8115.2014.12.012
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