Analysis of etiology of 1 101 cases of recurrent spontaneous abortion
Online published: 2015-03-26
Objective To analyze the etiology of recurrent spontaneous abortion and provide evidences for clinical diagnosis and treatment. Methods Data of 1 101 patients who were diagnosed as recurrent spontaneous abortion from January 2010 to October 2014 at the outpatient clinic of Department of Gynecology of Renji Hospital, Shanghai Jiao Tong University School of medicine were collected and the etiology of recurrent spontaneous abortion was analyzed. Results Among 1101 cases, analysis of maternal factors showed that the recurrent spontaneous abortion of 551 cases (50.05%), 148 cases (13.44%), and 402 cases (36.51%) were single cause, multi-causes, and unknown causes, respectively. Conclusion The etiology of recurrent spontaneous abortion is complicated, including maternal factors such as marital chromosomal abnormalities, reproductive tract anatomical abnormalities, autoimmune factors, endocrine abnormalities, and prothrombotic status, and embryonic factors such as embryonic chromosomal abnormalities, immune tolerance between maternal-fetal pregnancy imbalance, etc. Comprehensive and regular screening of causes for patients with recurrent spontaneous abortion before pregnancy and individualized treatment according to causes are vital for improving the rate of successful pregnancy.
Key words: recurrent; spontaneous abortion; etiology analysis; single cause; multi-causes
LIU Zhi-lan , KANG Xiao-min , ZHANG Xiao-xin , et al . Analysis of etiology of 1 101 cases of recurrent spontaneous abortion[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2015 , 35(3) : 396 . DOI: 11.3969/j.issn.1674-8115.2015.03.018
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