Journal of Shanghai Jiao Tong University (Medical Science) >

2015 , Vol. 35 >Issue 4: 470

DOI: https://doi.org/11.3969/j.issn.1674-8115.2015.04.002

Original article (Basic research)

Preliminary study on correlation between eukaryotic initiation factor 5A and spontaneous abortion

  • QIN Xiao-li ,
  • LIU Xiao-rui ,
  • TIAN Fu-ju ,
  • et al
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  • Department of Gynecology and Obstetrics, International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Online published: 2015-04-29

Supported by

National Natural Science Foundation of China， 31171439； National Funds for Distinguished Young Scientists of China， 81125004

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Abstract

Objective To investigate the correlation between eukaryotic initiation factor 5A (eIF5A) and spontaneous abortion. Methods Expressions of eIF5A-1 and eIF5A-2 in mouse uterine tissue of spontaneous abortion model and normal pregnancy controls and in decidua tissue of patients undergoing spontaneous abortion and artificial abortion were detected by immunofluorescence staining, real-time PCR, and Western blotting analysis. Results Both eIF5A-1 and eIF5A-2 were detected in mouse uterine tissue and human decidua tissue, but the expression of eIF5A-1 was significantly higher than that of eIF5A-2. The mRNA and protein expressions of eIF5A-1 and eIF5A-2 of the spontaneous abortion group were lower than those of the control group. Conclusion The down-regulation of eIF5A expression may be relevant to the occurrence and development of spontaneous abortion.

Key words： eukaryotic initiation factor 5A; spontaneous abortion; animal model

Cite this article

QIN Xiao-li , LIU Xiao-rui , TIAN Fu-ju , et al . Preliminary study on correlation between eukaryotic initiation factor 5A and spontaneous abortion[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2015 , 35(4) : 470 . DOI: 11.3969/j.issn.1674-8115.2015.04.002

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