Effects and mechanisms of sclerostin in bone metabolism
Online published: 2015-04-29
Supported by
National Natural Science Foundation of China, 81101360; Innovation Project of Science and Technology Commission of Shanghai Municipality, 12YZ053
Sclerostin is a glycoprotein encoding by SOST gene and can bind to Lrp4/5/6 receptor to block the Wnt signaling pathway, so as to regulate the bone metabolism. Mutations of the SOST gene are relevant to osterporosis and autosomal dominant diseases such as sclerosteosis, Van Buchem disease, and craniodiaphyseal dysplasia. Recent studies have confirmed that sclerostin can not only block the differentiation of osteoblast to inhibit bone formation by various ways, but also have a catabolic action through promotion of osteoclast formation and activation of osteocytes in a RANKL-dependent manner. The sclerostin monoclonal antibody may bring a new way for the treatment of osteoporosis. Currently, the clinical test is underway. The safety and validity of sclerostin monoclonal antibody need to be further researched.
Key words: sclerostin; bone metabolism; Wnt signaling pathway; osteoporosis
ZHANG Shuang , GAO Yan-hong . Effects and mechanisms of sclerostin in bone metabolism[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2015 , 35(4) : 589 . DOI: 11.3969/j.issn.1674-8115.2015.04.025
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