Brief original article

Effects of chronic sleep deprivation on expression of adipocytokine of young rats

  • CHEN Zhe ,
  • YANG Qian ,
  • CHEN Ting ,
  • et al
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  • 1.2010 Session of Preventive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2.Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 3.School of Public Health,Shanghai Jiao Tong University, Shanghai 200025, China

Online published: 2015-04-29

Supported by

National University Student Innovation Program, 201310248080

Abstract

Objective To investigate the effects of chronic sleep deprivation on the expression of circulating adipocytokine of young rats. Methods A total of 27 three-week-old Sprague-Dawley (SD) rats were randomly divided into the sleep deprivation group, recovery group, and control group. A motor-driven walking wheel method was adopted to establish the sleep deprivation model. The expressions of serum cytokines, including leptin, adiponectin, RBP-4, and Vaspin, were detected by the ELISA. The LEE's index was used to evaluate the adiposity status of rats. Results The LEE's index of the sleep deprivation group was significantly higher than that of the control group (P<0.05). Compared with the control group, RBP-4 levels of the sleep deprivation group and recovery group significantly decreased (P<0.1). Expressions of leptin, adiponectin, and Vaspin of 3 groups were not significantly different. Conclusion Chronic sleep deprivation results in the increase of adiposity status and decrease of RBP-4 expression in serum, which do not improve significantly with the recovery of sleep.

Cite this article

CHEN Zhe , YANG Qian , CHEN Ting , et al . Effects of chronic sleep deprivation on expression of adipocytokine of young rats[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2015 , 35(4) : 614 . DOI: 11.3969/j.issn.1674-8115.2015.04.030

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