Correlation between secreted frizzled-related protein 5 level and blood lipids in serum of patients with nonalcoholic fatty liver disease
Online published: 2015-06-04
Supported by
National Natural Science Foundation of China, 81271598; Natural Science Foundation of Chongqing, 2012-1-035
Objective To investigate the expression level of secreted frizzled-related protein 5 (SFRP5) in serum of patients with non-alcoholic fatty liver disease (NAFLD) and the correlation of SFRP5 and relevant influencing factors such as blood lipids. Methods A total of 58 patients with NAFLD were selected as subjects (experimental group) and 58 healthy people were selected from the Physical Examination Center as controls (control group). ELISA was used to detect the serum SFRP5 level and the correlation of SFRP5 of patients with NAFLD and relevant influencing factors was analyzed. Results Compared with the control group, levels of BMI, SBP, DBP, HbA1c, TG, TC, LDL-C, ApoB, UA, ALT, AST, γ-GGT, and SFRP5 of the experimental group were significantly higher (P<0.05 or P<0.01). Pearson correlation analysis showed that serum SFRP5 level negatively correlated with TC, HDL-C, and Apo-B (P<0.05 or P<0.01). Spearman correlation analysis showed that the serum SFRP5 level positively correlated with the content of liver fatty (P=0.029, r=0.287). Multivariate linear regression analysis showed that TC was the independent influencing factor of SFRP5. Conclusion Serum SFRP5 level of patients with NAFLD increases and positively correlates with the content of liver fatty and negatively correlates with TC, which suggest that there are chronic or acute compensatory mechanisms for counteracting liver fat accumulation, metabolic stress, and insulin resistance, and may contribute to delaying the development of NAFLD.
KANG Bing , PENG Chuan , ZUO De-yu , et al . Correlation between secreted frizzled-related protein 5 level and blood lipids in serum of patients with nonalcoholic fatty liver disease[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2015 , 35(5) : 694 . DOI: 11.3969/j.issn.1674-8115.2015.05.012
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