Luteinizing hormone receptor (LHR) plays a crucial role in the processes of reproduction and development. LHR can be down-regulated in response to preovulatory luteinizing hormone (LH) surge or by the administration of a pharmacological dose of human chorionic gonadotropin (hCG). LHR mRNA binding protein (LRBP) has been identified in ovarian cytoplasm of rats with down-regulated receptor. Researches show that the binding of LH/hCG and their receptors can stimulate the cAMP/PKA/ERK signaling pathway and expression of miR-122, which result in the increase of LRBP expression. The binding of LRBP with LHR mRNA can induce the suppression of translation and transfer to the p-bodies, which is closely relevant to the desensitivity of LHR during preovulatory phase. This paper reviews the research progresses of LRBP.