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Physiological functions of oxysterol 7α-hydroxylase and relevant research advances

  • ZHAO Xuan ,
  • SUN Yue-ping
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  • 1.Eight-year-program Clinical Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2.Department of Biochemistry and Molecular Cell Biology, Basic Medicine Faculty of Shanghai Jiao Tong University, Shanghai 200025, China

Online published: 2015-08-27

Abstract

Oxysterol 7α-hydroxylase (CYP7B1) is an enzyme that widely presents in organisms and performs a variety of physiological functions including promoting the generation of bile acid from cholesterol, metabolizing excessive oxysterol hormones, regulating the signaling pathway mediated by estrogen receptor, and regulating the immune system by acting on different substrates in different tissues. Recent studies show that the defection of CYP7B1 directly correlates with spastic paraplegia type 5 (SPG5) and congenital liver failure. This paper reviews physiological functions of CYP7B1 and relevant research advances.

Cite this article

ZHAO Xuan , SUN Yue-ping . Physiological functions of oxysterol 7α-hydroxylase and relevant research advances[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2015 , 35(7) : 1082 . DOI: 11.3969/j.issn.1674-8115.2015.07.028

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