Objective  To explore the necessity of treating Hasimoto thyroiditis patients with normal thyroid function by observing the changes of antibodies and cytokines relevant to thyroiditis after taking compound granules of Traditional Chinese Medicine. Methods  A total of 166 Hasimoto thyroiditis patients with normal thyroid function were randomly divided into the Traditional Chinese Medicine group (TCM group, n=55), placebo group (n=54), and EUTHYROX group (n=57). Changes of TPOAb, TgAb, CD195%, and CD30% in peripheral blood of patients before and after treatment were compared. Results  CD30% and CD195% of the TCM group significantly decreased after treatment (P<0.01), while CD30% and CD195% of placebo group and EUTHYROX group mildly increased after treatment (P>0.05). TPOAb and TgAb levels of the TCM group significantly decreased after treatment and the differences of three groups were statistically significant (P<0.01). Spearman correlation analysis showed that TgAb negatively correlated with CD30% and CD195%, while TPOAb did not correlate with CD30% and CD195%. Conclusion  Traditional Chinese Medicine compound can decrease high levels of TPOAb and TgAb and inhibit positive expressions of CD30 and CD195, which indicates Traditional Chinese Medicine can regulate locally disordered immune status of thyroid.