Objective  To explore the protein expression of LRIG3 in tissues of cervical squamous cell carcinoma and the correlation between the protein expression of LRIG3 and cell proliferation. Methods  The paraffin embedded specimens of 45 cases of cervical squamous cell carcinoma, 20 cases of cervical intraepithelial neoplasia (CIN), and 30 cases of normal cervical tissues from 2009 to 2011 were collected from the Pathology Department of the First Affiliated Hospital of Zhengzhou University. Immunohistochemical SP method was adopted to detect the protein expressions of LRIG3 and Ki-67 in cervical tissues and statistical analysis was performed. Results  The positive expression rates of LRIG3 in tissues of cervical squamous cell carcinoma and CIN and normal cervical tissues were 35.56%, 70.00%, and 100.00%, respectively and the differences were statistically significant (P<0.05). The positive expression rates of Ki-67 in tissues of cervical squamous cell carcinoma and CIN and normal cervical tissues were 86.67%, 30.00%, and 3.33%, respectively and the differences were statistically significant (P<0.01). The expression of LRIG3 significantly correlated with the expression of Ki-67 (P<0.01). Conclusion  The low protein expression of LRIG3 in tissues of cervical squamous cell carcinoma is relevant to the proliferation of tumor cells, which suggests the down-regulation of LRIG3 may be relevant to cervical squamous cell carcinoma.