Correlation between response inhibition function and behavioral inhibition/activation systems of patients with obsessive-compulsive disorder
Online published: 2015-12-22
Supported by
Medicine Guidance Project of Science and Technology Commission of Shanghai Municipality, 124119a8601; Biomedical Engineering Cross Research Foundation of Shanghai Jiao Tong University, YG2013MS65; The National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH 2011-873
ObjectiveTo investigate the changes of response inhibition function of patients with obsessive-compulsive disorder (OCD) and its correlation with the activity of behavioral inhibition system/behavioral activation system (BIS/BAS).MethodsA total of 45 patients with OCD and 49 healthy controls were enrolled. The response inhibition function was assessed by the stop signal task (SST). BIS/BAS scale was used to perform the psychological assessment and the differences between two groups were compared.Results①SST: the stop signal reaction time (SSRT) of the OCD group [(351.16±48.18) ms] was significantly shorter than that of the control group [(389.65±30.47) ms](P<0.01). The rates of go success (GS) of the OCD group [(75.67±15.70)%] were significantly lower than those of the control group ([86.45±10.23)%](P<0.01). ②BIS/BAS scale: the scores of BIS of the OCD group (11.53±2.86) were significantly higher than those of the control group (9.39±3.32) (P<0.01). The difference of scores of BAS between two groups were not statistically significant (P>0.05). ③The scores of BIS of OCD patients with better response inhibtion function were significantly higher than those of other patients and controls (P<0.05).ConclusionThe response inhibition function of patients with OCD is enhanced and affected by the activity of BIS.
WANG Yuan , WANG Zhen , ZHANG Hai-yin , CHEN Jue , ZHAO Qing , XIAO Ze-ping . Correlation between response inhibition function and behavioral inhibition/activation systems of patients with obsessive-compulsive disorder[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2015 , 35(10) : 1502 . DOI: 10.3969/j.issn.1674-8115.2015.10.014
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