Objective  To evaluate the life quality of patients with axial spondyloarthritis (SpA) and discuss the influencing factors in terms of demography, inflammation level, disease activity, and the degree of functional impairment. Methods  A total of 213 patients with axial SpA were selected. Patients' quality of life was evaluated by SF12-v2 health survey and factors influencing the quality of life were analyzed. Results  Compared with normal people, the quality of life of patients with axial SpA significantly decreased (P<0.05). Scores of all dimensions (except the vitality) of SF12-v2 and physical component summary (PCS) of the normal erythrocyte sedimentation rate (ESR) group were higher than those of increased ESR group (P<0. 05). Scores of all dimensions (except the vitality) of SF12-v2, PCS, and mental component summary (MCS) of the low disease activity group (BASDAI<4, ASDAS<2.1) were higher than those of high disease activity group (BASDAI≥4, ASDAS≥2.1) (P<0. 05). Scores of all dimensions (except the vitality) of SF12-v2, PCS, and MCS of the good functional status group (BASFI<5) were higher than those of poor functional status group (BASFI≥5) (P<0. 05). Scores of all dimensions of SF12-v2, PCS, and MCS were significantly correlated with ASDAS and BASFI (P<0.05). Scores of all dimensions of SF12-v2 and PCS were significantly correlated with ESR, CRP, BASDAI, and BASMI (P<0.05). Multiple linear stepwise regression analysis showed that PCS was linearly correlated with ASDAS and BASFI. Conclusion  The quality of life of patients with axial SpA is markedly lower than that of normal people. The quality of life is significantly correlated with inflammation level (ESR and CRP), disease activity (BASDAI and ASDAS), and the degree of functional impairment (BASFI and BASMI).