Objective  To evaluate the rationality of the use of glucose lowering drugs for the Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine. Methods  The drug use and evaluation method was adopted and drug use information of patients with type 2 diabetes who were admitted by the Renji Hospital South Campus from the first quarter of 2013 to the second quarter of 2015 was collected and statistically analyzed. Results  The prescriptions of glucose lowering drugs increased annually. The sales amount of the second quarter of 2015 was about 3 times higher than that of the first quarter of 2013. Insulin drugs accounted for about 50% and both the sales amount and defined daily dose (DDD) of general insulin injection (domestic) were ranked as No.1 among all drugs. According to DDDs, commonly used oral glucose lowering drugs were gliclazide (imported), metformin (imported), and voglibose (imported). There were 6 drugs (24%) and 16 drugs (64%) with the ratio of ranks of sales amount and DDD larger than 1 and smaller than 1. Conclusion  The prescriptions and sales amount of glucose lowering drugs of Renji Hospital South Campus increase significantly with the number of outpatients with type 2 diabetes. Basically, the use of the glucose lowering drugs is reasonable, but drugs with better synchronization of the cost and the frequency should be used.