Original article (Basic research)

Correlation between polymorphism of resistin gene and cerebral infraction

  • GU Lin ,
  • CAI Gao-yu ,
  • CHEN Chun ,
  • et al
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  • Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Online published: 2016-03-29

Abstract

Objective To investigate the correlation between the polymorphism of locus -420C/G of the resistin gene and cerebral infraction. Methods The polymorphism of locus -420C/G of the resistin gene of 426 patients with cerebral infraction and 305 healthy controls was analyzed by PCR-LDR. Results The difference of TC between the cerebral infraction group and control group were not statistically significant. The TG, LDL-C, fasting blood glucose, and blood pressure of the cerebral infraction group were higher than those of the control group, while HDL-C was lower than that of the control group. The differences of genotype frequency and allele frequency of -420C/G gene between the cerebral infraction group and control group were not statistically significant. Samples of both groups accorded with the H-W test. The logistic regression analysis showed that sytolic pressure, fasting blood glucose, LDL-C, and TG were independent risk factors of cerebral infraction. Conclusion The polymorphism of locus -420 C/G of the resistin gene does not correlate to cerebral infraction.

Cite this article

GU Lin , CAI Gao-yu , CHEN Chun , et al . Correlation between polymorphism of resistin gene and cerebral infraction[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2016 , 36(2) : 229 . DOI: 10.3969/j.issn.1674-8115.2016.02.015

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