Research progress of bone-targeting estrogen-like drugs in treatment of osteoporosis
Online published: 2017-06-02
Supported by
National Natural Science Foundation of China, 81101360; Shanghai Science and Technology Committee Foundation, 12YZ05; Scientific Research Foundation of Ministry of Education of China for Returned Overseas Scholars, group 47
Estrogen-like drugs are efficient for prevention and treatment of osteoporosis. In order to improve absorptivity and bioavailability for estrogen-like drugs in human body, enhance affinity between estrogen-like drugs and skeletal system, and reduce adverse reactions due to long term administration, new improvements in estrogen-like drugs have been made in terms of drug targeting and drug synthesis in recent years. Estrogen controlled release nano-carriers and some small peptide, tetracycline and RGD-peptide bone-targeting drugs are widely used, which provide novel methods and ideas for osteoporosis treatment. In this paper, research progresses of estrogen-like drugs are reviewed.
Key words: osteoporosis; estrogen; nanocarrier; bonetargeting
HU Yan , GAO Yan-hong . Research progress of bone-targeting estrogen-like drugs in treatment of osteoporosis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2016 , 36(3) : 437 . DOI: 10.3969/j.issn.16748115.2016.03.026
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